Faculty details

Prof.Parthasarathi Das

Designation: Professor

Department: Chemistry and Chemical Biology

Email: partha[at]iitism[dot]ac[dot]in

Contact Number: 9419227993

Office Number: +91-326-223-913262235012

Personal Page: Click Here

About Me: I am trained Organic & Medicinal Chemist with 25 years of experience in pharmaceutical industry and academic.

Research Interest: Organic Synthesis and Medicinal Chemistry

Teaching

  • CYI101 Chemistry Common (B.Tech)

  • CYC 516 Strategies in organic synthesis (M.Sc)

  • CYC 525 Basic of Pharmacology & Drug Design (M.Tech)

  • CYD 501 Medicinal Chemistry (M.Sc)

  • CYC 540  Research Methodology (Ph.D.) 

  • ACE 34159 Medicinal Chemistry (M.Sc)

  • ACC 33144 Modern Methods in Organic Synthesis (M.Sc)

  • ACC 31232 Organic Practical (M.Sc)

  • ACC 11101 Organic Chemistry (B.Tech)

  • ACC 11201 Organic Practical (B.Tech)

  • CHEM-IIIM-2-005 Advanced Organic Chemistry (AcSIR)

  • CHEM-IIIM-3-009 Medicinal Chemistry /Organic Synthesis/Natural Product (AcSIR)

Academics

EDUCATION
  • Doctor of Philosophy (Ph.D), Organic Chemistry, CSIR-National Chemical Laboratory, University of Poona, India​

POSTDOCTORAL EXPERIENCE
  • Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 

  • Department of Chemistry, Tohoku University, Sendai, Japan 

  • Institut für Organische Chemie, RWTH-Aachen, Aachen, Germany 

 

Position

Academic (2012- till date)
  • Dean (R&D) , Indian Institute of Technology (ISM) Dhanbad, India

  • Professor, Indian Institute of Technology (ISM) Dhanbad, India

  • Associate Professor, Indian Institute of Technology (ISM) Dhanbad, India

  • Principal Scientist, CSIR Indian Institute of Integrative Medicine, Jammu, India  

 

Industry (2003-2011)
  • Research Investigator Chemistry-Lead, Dr. Reddy’s Laboratories Ltd., Hyderabad, India   

  • Associate Director, Discovery Research, Dr. Reddy’s Laboratories Ltd., Hyderabad, India 

Awards and Honors

  • Parthasarathi Das joined international advisory board of New Journal of Chemistry
  • Parthasarathi Das appointed as Research Council Member of CSIR-Indian Institute of Integrative Medicine Jammu
  • Fellow of the Royal Society of Chemistry (FRSC) (2020)
  • Council Member, Chemical Research Society of India (CRSI) (2020-2023)
  • Chemical Research Society of India (CRSI) Bronze Medal
  • PEC Member, Technology Development Board (TDB), Department of Science and Technology (DST), Govt. India
  • Publons Peer Review Awards 2019
  • Prof. K. N. Johry Memorial Lecture Award, University of Delhi
  • Featured in the “TCI-India League of Extraordinary Chemists”
  • Panel Member ACS-Dr. Reddy's Symposium on Recent Advances in Drug Development 2016
  • Harvard Post Doctoral Fellowship, Harvard University, USA 2002
  • CREST-Postdoctoral Fellowship, Japan Science and Technology (JST)
  • Graduiertenkollegs Fellowship, DFG, Germany

Publications

List Of Research Publications (only in Peer-reviewed Journals)

 
  • Site selective Heck arylation of N-vinyl-7-azaindole engineered by N-oxide activation: scope and mechanistic studies, Susanta Patra, Arunava Sengupta and Parthasarathi Das*Org. Chem. Front., 2025, 12, 5379-5386.

  • Arylthianthrenium Salts Enabled Palladium-Catalyzed Regioselective Arylation: Access to Value-Added 7-Azaindoles, Siddhartha Paul, Vishal Talukdar, Diship Srivastava, Niladri Patra and Parthasarathi Das*, Org. Lett. 2025, 27, 36, 9987–9992.

  • (Methyl)thianthrenium Salt Enabled Monoselective N-Methylation and N-(13C-Methyl) Labeling: Late-Stage Functionalization of Arylamides, Aahif Iqubal, Arijit Jash and Parthasarathi Das*, Org. Lett. 2025, 27, 28, 7643–7648.
  • CuF2-Catalyzed Chan–Lam Reaction of Saccharin: Solvent-Controlled Chemodivergent Synthesis of N-Arylsaccharin and Methyl 2-(N-Arylsulfamoyl)benzoates, Tanumay Roy, Subhas Jana and Parthasarathi Das*, J. Org. Chem. 2025, 90, 26, 9083–9097.
  • HFIP-Promoted Regioselective Hydrofunctionalization of Enamides and N-Vinyl Azoles, Susanta Patra, Satyajit Samanta, Vishal Talukdar and Parthasarathi Das*, J. Org. Chem. 2025, 90, 18, 6261–6277.
  • CuF2/DTBP-Catalyzed Chan-Lam Coupling of Oxazolidinones with Arylboronic Acid Pinacol Ester: Scope and Application, Tanumay Roy, Krishanu Mondal, Pallabi Halder, Arunava Sengupta and Parthasarathi Das*, J. Org. Chem. 2025, 90, 18, 6219–6232.
  • CuF2-Catalyzed C-N Cross-Coupling of Aryl Silanes: Expanding the Scope of Chan-Lam Type Reaction, Vishal Talukdar, Siddhartha Paul, Krishanu Mondal and Parthasarathi Das*, Adv. Syn. Cat. 2025, 367, e202401498.
  • Ex Situ Generation of D2 for Reductive Deuteration: Scope and Application to Late-Stage Functionalization, Ashif Iqubal, Arijit Jash, Pallabi Halder and Parthasarathi Das*, J. Org. Chem. 2025, 90, 4, 1571–1584.
  • Pd(II)-Catalyzed Tandem Intramolecular Oxidative Heck Reaction/ C–H Arylation Sequence: One-Pot Synthesis of 3-Nitro-2-Aryl-Indoles, Mohit K Tiwari#, Muskan# and Parthasarathi Das*, Asian. J. Org. Chem. e202400692.
  • Iodine-Catalyzed Regioselective C-3 Chalcogenation of 7-Azaindoles: Access to Benzothiophene-Fused 7-Azaindole Analogs, Krishanu Mondal#, Siddhartha Paul#, Pallabi Halder, Vishal Talukdar, and Parthasarathi Das*, J. Org. Chem. 2024, 89, 23, 17042–17058.
  • Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation, Mousumi Deb, Hoshiyar Singh, Diksha Manhas, Utpal Nandi, Santosh K. Guru and Parthasarathi Das*, RSC Med. Chem., 2024,15, 3097-3113
  • Exploiting Chloroform-COware Chemistry for Pd-Catalyzed Carbonylation of Naturally Occurring and Medicinally Relevant Phenols, Pallabi Halder, Krishanu Mondal, Arijit Jash and Parthasarathi Das*, J. Org. Chem. 2024, 89, 13, 9275–9286.
  • Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper(II) Catalyst: Scope and Application to Drug Synthesis, Vishal Talukdar, Krishanu Mondal, Pallabi Halder, and Parthasarathi Das*, J. Org. Chem. 2024, 89, 11, 7455–7471
  • Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy, Pallabi Halder, Anubhav Rai, Vishal Talukdar Parthasarathi Das*, and Naga Rajiv Lakkaniga*, RSC Med. Chem., 2024,15, 1452-1470.
  • Oxidative Alkynylation of 7-Azaindoles: Synthetic Scope and Mechanistic Studies Vishal Talukdar, Krishanu Mondal, Devendra Kumar Dhaked, and Parthasarathi Das* Chem Asian J. 2024, e202300987 (Highlighted HOT Article Wiley-Vch)
  • Two-Chamber-Enabled Hydrogenation Reactions Using Al‑H2O/NaOH: Access to Pharmaceuticals Ashif Iqubal, Pallabi Halder, and Parthasarathi Das* J. Org. Chem. 2023, 88, 17047−17061 (Highlighted in Synfacts)
  • 7-Azaindole N-Oxide (7-AINO) Mediated Cu-Catalyzed N-Arylation: Mechanistic Investigation into the Role of Fluoride Ions Krishanu Mondal, Narottam Mukhopadhyay, Susanta Patra, Tanumay Roy, and Parthasarathi Das* ACS Catal. 2023, 13, 11977-11995.
  • Carbonylative Transformations Using a DMAP-Based Pd-Catalyst through Ex Situ CO Generation Pallabi Halder, Ashif Iqubal, Krishanu Mondal, Narottam Mukhopadhyay, and Parthasarathi Das* J. Org. Chem. 2023, 88, 15218−15236.
  • CuF2/MeOH-Catalyzed N3-Selective Chan-Lam Coupling of Hydantoins: Method and Mechanistic Insight Tanumay Roy, Krishanu Mondal, Arunava Sengupta, and Parthasarathi Das* J. Org. Chem. 2023, 88, 9, 6058–6070 (Highlighted in organic portal https://www.organic-chemistry.org/)
  • CuF2/DMAP-Catalyzed N-Vinylation: Scope and Mechanistic Study, Krishanu Mondal, Susanta Patra, Pallabi Halder, Narottam Mukhopadhyay and Parthasarathi Das* Org. Lett. 2023, 25, 8, 1235–1240. (Highlighted in organic portal https://www.organic-chemistry.org/)
  • Exploiting Coordination Behavior of 7-Azaindole for Mechanistic Investigation of Chan-Lam Coupling and Application to 7-Azaindole Based Pharmacophores, Krishanu Mondal, Narottam Mukhopadhyay, Arunava Sengupta, Tanumay Roy, Parthasarathi Das* Chem. Eur. J. 2023, e202203718.
  • Palladium-Catalyzed Aminocarbonylation of Isoquinolines Utilizing Chloroform-COware Chemistry, Pallabi Halder, Vishal Talukdar, Ashif Iqubal and Parthasarathi Das* J. Org. Chem. 2022, 87, 21, 13965–13979.

Projects & Activities

Sponsored Research Projects (External Funded)

On going Project:
  • Development of “Chloroform COware Chemistry” as Toolbox for Safe Carbonylative Transformations (SERB(CRG)(416)/2023-2024/1085/CCB) (DST-SERB)
  • Creation of nodal centers for the production of imported APIs, KSMs and Intermediates to achieve self-sufficiency in health-care sector (DST(TDT)(393)/2023-2024/1030/CCB) (DST)
  • Modular Synthesis of Fluorinated Azole Pharmaceuticals using Chan-Lam Coupling Variants (DST(SERB)(350)/2022-2023/946/CCB) (DST-SERB)
  • Application of Two-Chamber Reactors for Safe Carbonylation Reactions: Affordable Synthesis of Stable Isotope Labelled Drug Standards (DAE(BRNS)(8)/2021-2022/827/CHEMISTRY) (DAE-DRNS)
Completed Project:
  • Identification and in vivo validation of c-Jun-N-Terminal Kinase 3 (JNK-3) inhibitors as novel therapeutics for neurodegenerative diseases (DST(SERB)(237)/2019-2020/661/CHEMISTRY)(DST-SERB)

Other Academic and Administrative Activities

Industrial Collaboration and Translational Research
  • AarogyaAI (https://aarogya.ai/) a startup Biotech Company aims to diagnose Drug-Resistant Tuberculosis (DR-TB) using Artificial Intelligence. @IITISM_DHANBAD has signed MOU with AarogyaAI a Biotech Company aims to cooperate in participating academic and research activities in the area of Drug Discovery, Bioinformatics, Artificial Intelligence and Machine Learning in Healthcare and Human Well Being on 01 Oct, 2021.
  •  IIT(ISM) Dhanbad and Tokyo Chemical Industry Co, Ltd (TCI), Japan have signed a MOU on 12 th July 2022 Material Transfer Agreement (MTA) for fine & specialty chemical products. -An initiative from Bench to Market

Guidance

Ph.D Supervision
  • Ph.D awarded under my guidance: 15 (10 from CSIR-IIIM Jammu, 5 from IIT ISM Dhanbad)
  • Ph.D Students registered and ongoing: 14
Ongoing Ph.D Students
1. Mousumi Deb, PMRF SRF
2. Susanta Patra, PMRF SRF
3. Muskan, IIT(ISM) SRF
4. Siddhartha Paul, IIT(ISM) SRF
5. Shreyasi Jana, IIT(ISM) SRF 
6. Arijit Jash, CSIR SRF 
7. Satyajit Samanta, CSIR SRF 
8. Bedanta Sengupta, IIT(ISM) SRF 
9. Subhas Jana, CSIR JRF 
10. Riya Kuiry, CSIR JRF
11. Souvik Karmakar, DST(SERB) JRF
12. Amit Banerjee, DST-INSPIRE JRF
13. Shreya Adhikary, CSIR JRF
14. Sain Hossain, DST-INSPIRE JRF